2009, discovery of a whole new phenotype for germs in narrow nanofluidic slits; and 1st detection of regional protein constructions alongside DNA employing stable-condition nanopores
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Deposition and atomic force microscopy of individual phthalocyanine polymers between nanofabricated electrodes
2010, created a whole new way (‘wedging transfer’) to control nanostructures; initially report of DNA translocation as a result of graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into strong-state nanopores
Our investigation ranges through the biophysics of DNA to synthetic cells and over and above. Remember to have a look below in the spectrum of our current projects.
‘At the outset we checked out biological techniques that has a physical check out and acted on The idea with the tools we knew. It took a couple of years in advance of we started Doing work additional on the massive biological problems. I then started to phone it nanobiology, a time period that didn't exist at the time.
Nanopores depict a chic and adaptable Software to evaluate one molecules. We investigate novel detection modes with good-point out nanopores together with several tips on how to evaluate proteins with nanopores. Assignments encompass the next:
‘You should not just think about the questions of tomorrow, but also consider the questions of the day just after tomorrow’
Dekker started off his analysis on single carbon nanotubes in 1993 when he arrange a different line of analysis to check electrical transportation via one natural molecules concerning nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was accomplished inside of a collaboration Together with the group ceesdekker of Nobel laureate Richard Smalley. STM and nanolithography tactics were accustomed to show that these nanotubes are quantum wires at The one-molecule level, with remarkable physical Houses.
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion towards roadblock-traversal experiments
Character Physics many thanks the anonymous reviewers for his or her contribution on the peer evaluation of the perform.
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2013, managed shaping of Stay bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes